Saturday, August 13th, 2022

Bills vs Colts (Preseason)

| 4:00 pm | NATL - NFL | Highmark Stadium One Bills Drive Orchard Park NY 14127 USA | see more
Saturday, August 20th, 2022

Bills vs Broncos (Preseason) (Date/time subject to change)

| NATL - NFL | Highmark Stadium One Bills Drive Orchard Park NY 14127 USA | see more
Saturday, August 27th, 2022

Bills at Panthers (Preseason) (Date/time subject to change)

| NATL - NFL | Bank of America Stadium 800 South Mint Street Charlotte NC 28202 USA | see more
Thursday, September 8th, 2022

Bills at Rams

| 8:20 pm | NATL - NFL | SoFi Stadium 1000 S Prairie Ave Inglewood CA 90301 USA | see more
Monday, September 19th, 2022

Bills vs Titans

| 7:15 pm | NATL - NFL | Highmark Stadium One Bills Drive Orchard Park NY 14127 USA | see more
Sunday, September 25th, 2022

Bills at Dolphins

| 1:00 pm | NATL - NFL | Hard Rock Stadium 2269 Northwest 199th Street Miami Gardens FL 33056 USA | see more
Sunday, October 2nd, 2022

Bills at Ravens

| 1:00 pm | NATL - NFL | M&T Bank Stadium 1101 Russell Street Baltimore MD 21230 USA | see more
Sunday, October 9th, 2022

Bills vs Steelers

| 1:00 pm | NATL - NFL | Highmark Stadium One Bills Drive Orchard Park NY 14127 USA | see more
Sunday, October 16th, 2022

Bills at Chiefs

| 4:25 pm | NATL - NFL | GEHA Field at Arrowhead Stadium One Arrowhead Drive Kansas City MO 64129 USA | see more
Sunday, October 30th, 2022

Bills vs Packers

| 8:20 pm | NATL - NFL | Highmark Stadium One Bills Drive Orchard Park NY 14127 USA | see more
Sunday, November 6th, 2022

Bills at Jets

| 1:00 pm | NATL - NFL | MetLife Stadium One MetLife Stadium Drive East Rutherford NJ 07073 USA | see more
Sunday, November 13th, 2022

Bills vs Vikings

| 1:00 pm | NATL - NFL | Highmark Stadium One Bills Drive Orchard Park NY 14127 USA | see more
Sunday, November 20th, 2022

Bills vs Browns

| 1:00 pm | NATL - NFL | Highmark Stadium One Bills Drive Orchard Park NY 14127 USA | see more
Thursday, November 24th, 2022

Bills at Lions

| 12:30 pm | NATL - NFL | Ford Field 2000 Brush Street Detroit MI 48226 USA | see more
Thursday, December 1st, 2022

Bills at Patriots

| 8:15 pm | NATL - NFL | Gillette Stadium One Patriot Place Foxborough MA 02035 USA | see more
Sunday, December 11th, 2022

Bills vs Jets

| 1:00 pm | NATL - NFL | Highmark Stadium One Bills Drive Orchard Park NY 14127 USA | see more
Sunday, December 18th, 2022

Bills vs Dolphins (Date/time subject to change)

| 1:00 pm | NATL - NFL | Highmark Stadium One Bills Drive Orchard Park NY 14127 USA | see more
Saturday, December 24th, 2022

Bills at Bears

| 1:00 pm | NATL - NFL | Soldier Field 1410 South Museum Campus Drive Chicago IL 60605 USA | see more
Monday, January 2nd, 2023

Bills at Bengals

| 8:30 pm | NATL - NFL | Paul Brown Stadium One Paul Brown Stadium Cincinnati OH 45202 USA | see more
Sunday, January 8th, 2023

Bills vs Patriots (Date/time subject to change)

| 1:00 pm | NATL - NFL | Highmark Stadium One Bills Drive Orchard Park NY 14127 USA | see more