Saturday, August 13th, 2022
Bills vs Colts (Preseason)
| 4:00 pm | NATL - NFL | Highmark Stadium One Bills Drive Orchard Park NY 14127 USA | see moreSaturday, August 20th, 2022
Bills vs Broncos (Preseason) (Date/time subject to change)
| NATL - NFL | Highmark Stadium One Bills Drive Orchard Park NY 14127 USA | see moreSaturday, August 27th, 2022
Bills at Panthers (Preseason) (Date/time subject to change)
| NATL - NFL | Bank of America Stadium 800 South Mint Street Charlotte NC 28202 USA | see moreThursday, September 8th, 2022
Bills at Rams
| 8:20 pm | NATL - NFL | SoFi Stadium 1000 S Prairie Ave Inglewood CA 90301 USA | see moreMonday, September 19th, 2022
Bills vs Titans
| 7:15 pm | NATL - NFL | Highmark Stadium One Bills Drive Orchard Park NY 14127 USA | see moreSunday, September 25th, 2022
Bills at Dolphins
| 1:00 pm | NATL - NFL | Hard Rock Stadium 2269 Northwest 199th Street Miami Gardens FL 33056 USA | see moreSunday, October 2nd, 2022
Bills at Ravens
| 1:00 pm | NATL - NFL | M&T Bank Stadium 1101 Russell Street Baltimore MD 21230 USA | see moreSunday, October 9th, 2022
Bills vs Steelers
| 1:00 pm | NATL - NFL | Highmark Stadium One Bills Drive Orchard Park NY 14127 USA | see moreSunday, October 16th, 2022
Bills at Chiefs
| 4:25 pm | NATL - NFL | GEHA Field at Arrowhead Stadium One Arrowhead Drive Kansas City MO 64129 USA | see moreSunday, October 30th, 2022
Bills vs Packers
| 8:20 pm | NATL - NFL | Highmark Stadium One Bills Drive Orchard Park NY 14127 USA | see moreSunday, November 6th, 2022
Bills at Jets
| 1:00 pm | NATL - NFL | MetLife Stadium One MetLife Stadium Drive East Rutherford NJ 07073 USA | see moreSunday, November 13th, 2022
Bills vs Vikings
| 1:00 pm | NATL - NFL | Highmark Stadium One Bills Drive Orchard Park NY 14127 USA | see moreSunday, November 20th, 2022
Bills vs Browns
| 1:00 pm | NATL - NFL | Highmark Stadium One Bills Drive Orchard Park NY 14127 USA | see moreThursday, November 24th, 2022
Bills at Lions
| 12:30 pm | NATL - NFL | Ford Field 2000 Brush Street Detroit MI 48226 USA | see moreThursday, December 1st, 2022
Bills at Patriots
| 8:15 pm | NATL - NFL | Gillette Stadium One Patriot Place Foxborough MA 02035 USA | see moreSunday, December 11th, 2022
Bills vs Jets
| 1:00 pm | NATL - NFL | Highmark Stadium One Bills Drive Orchard Park NY 14127 USA | see moreSunday, December 18th, 2022
Bills vs Dolphins (Date/time subject to change)
| 1:00 pm | NATL - NFL | Highmark Stadium One Bills Drive Orchard Park NY 14127 USA | see moreSaturday, December 24th, 2022
Bills at Bears
| 1:00 pm | NATL - NFL | Soldier Field 1410 South Museum Campus Drive Chicago IL 60605 USA | see moreMonday, January 2nd, 2023
Bills at Bengals
| 8:30 pm | NATL - NFL | Paul Brown Stadium One Paul Brown Stadium Cincinnati OH 45202 USA | see moreSunday, January 8th, 2023