Sunday, September 13th, 2026

Buffalo Bills at Houston Texans

| 1:00 pm | NATL - NFL | NRG Stadium
Thursday, September 17th, 2026

Detroit Lions at Buffalo Bills

| 8:15 pm | NATL - NFL | Highmark Stadium
Sunday, September 27th, 2026

Los Angeles Chargers at Buffalo Bills

| 1:00 pm | NATL - NFL | Highmark Stadium
Sunday, October 4th, 2026

New England Patriots at Buffalo Bills

| 1:00 pm | NATL - NFL | Highmark Stadium
Monday, October 12th, 2026

Buffalo Bills at Los Angeles Rams

| 8:15 pm | NATL - NFL | SoFi Stadium
Sunday, October 18th, 2026

Buffalo Bills at Las Vegas Raiders

| 4:25 pm | NATL - NFL | Allegiant Stadium
Sunday, November 1st, 2026

Baltimore Ravens at Buffalo Bills

| 1:00 pm | NATL - NFL | Highmark Stadium
Monday, November 9th, 2026

Buffalo Bills at Minnesota Vikings

| 8:15 pm | NATL - NFL | U.S. Bank Stadium
Sunday, November 15th, 2026

Buffalo Bills at New York Jets

| 1:00 pm | NATL - NFL | MetLife Stadium
Sunday, November 22nd, 2026

Miami Dolphins at Buffalo Bills

| 1:00 pm | NATL - NFL | Highmark Stadium
Thursday, November 26th, 2026

Kansas City Chiefs at Buffalo Bills

| 8:20 pm | NATL - NFL | Highmark Stadium
Sunday, December 6th, 2026

Buffalo Bills at New England Patriots

| 4:25 pm | NATL - NFL | Gillette Stadium
Sunday, December 13th, 2026

Buffalo Bills at Green Bay Packers

| 8:20 pm | NATL - NFL | Lambeau Field
Saturday, December 19th, 2026

Chicago Bears at Buffalo Bills

| 8:20 pm | NATL - NFL | Highmark Stadium
Friday, December 25th, 2026

Buffalo Bills at Denver Broncos

| 4:30 pm | NATL - NFL | Empower Field at Mile High
Sunday, January 3rd, 2027

Buffalo Bills at Miami Dolphins

| 1:00 pm | NATL - NFL | Hard Rock Stadium
Sunday, January 10th, 2027

New York Jets at Buffalo Bills

| 1:00 pm | NATL - NFL | Highmark Stadium